Brand Name: CELEBREX
CLASSIFICATIONS
Therapeutic:
Anti-rheumatics, NSAIDS
Pharmacologic:
COX-2 inhibitors
ACTIONS
Physiologic Mechanism
• Decreased pain and inflammation caused by arthiritis
Pharmacologic Mechanism
• Prevention of M Inhibits the enzyme COX-2. This enzyme is required for the synthesis of prostaglandins.
• Has analgesic, anti-inflammatory, and antipyretic properties.
INDICATION
• Relief of signs and symptoms of osteoarthritis.
• Relief of signs and symptoms of rheumatoid arthritis in adults.
NURSING CONSIDERATIONS
• Assess patient’s range of motion, degree of swelling, and pain in affected joints before and periodically throughout therapy.
• Assess patient for allergy to sulfonamides, aspirin, or NSAIDS. Patients with these allergies should not receive celecoxib.
• May be administered without regard to meals.
• Instruct patient to take celecoxib exactly as directed. Do not take more than prescribed dose. Increasing doses does not appear to increase effectiveness.
• Advise patient to notify health care professional promptly if signs or symptoms of GI toxicity (abdominal pain, black stools), skin rash, unexplained weight gain, edema occurs.
•Patient should discontinue celecoxib and notify health care professional if signs and symptoms of hepatotoxicity (nausea, fatigue, lethargy, pruritus, jaundice, upper right quadrant tenderness, flu-like symptoms) occur.