Loss of control of blood glucose
When a patient stabilized on any diabetic regimen is exposed to stress such as fever, trauma, infection, or surgery, a loss of control may occur. At such times, it may be necessary to add insulin in combination with glimepiride or even use insulin monotherapy.
Pregnancy
Glimepiride is not recommended for use during pregnancy.
Nursing mothers
It is not known whether glimepiride is distributed into human breast milk. However, some sulfonylureas are distributed into human breast milk. Because of its potential to cause hypoglycemia in nursing infants, glimepiride is not recommended for use by nursing mothers.
Pediatric use
Glimepiride is not recommended for use in children.
Drug interactions
• The hypoglycemic action of sulfonylureas may be potentiated by certain drugs, including nonsteroidal anti-inflammatory drugs and other drugs that are highly protein bound, such as salicylate, sulfonamide, chloramphenicol, coumarins, probenecid, monoamine oxidase inhibitors, and beta adrenergic blocking agents. When these drugs are administered to a patient receiving glimepiride, the patient should be observe closely for hypoglycemia.
• Certain drugs tend to produce hyperglycemia and may lead to loss of control. These drugs include the thiazide and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, and isoniazid. When these drugs are administered to a patient receiving glimepiride, the patient should be closely observed for loss of control.
• Glimepiride is metabolized by cytochrome P450 2C9 (CYP2C9). This should be taken into account when glimepiride is co-administered with inducers, inhibitors or substrates of CYP2C9 (e.g. rifampin, fluconazole, amiodarone, tolbutamide, diclofenac, ibuprofen, naproxen).
• H2 receptor antagonists, beta-blockers, clonidine and reserpine may lead to either potentiation or weakening of the blood-glucose-lowering effect.
• Concomitant treatment with a beta-receptor blocker, clonidine guanethidine or reserpine may mask the warning symptoms of a hypoglycemic attack.
• Acute and chronic alcohol intake may either potentiate or attenuate the activity of glimepiride in an unpredictable fashion.
Storage:
Store at temperature not exceeding 30 degrees Celcius.
Protect from sunlight and moisture.
The expiration date refers to the product correctly stored at the require conditions.
Availabiliy:
Glimepiride (Getryl) Tablets 1mg are available in blister packs of 20 tablets.
Glimepiride (Getryl) Tablets 2mg are available in blister packs of 20 tablets.
Glimepiride (Getryl) Tablets 3mg are available in blister packs of 20 tablets.
Glimepiride (Getryl) Tablets 4mg are available in blister packs of 20 tablets.
Caution:
Foods, Drugs, Devices, and Cosmetics Act prohibits dispensing without prescription.
Keep out of reach of children
