Pharmacology
(1) Bronchodilative action
The bronchodilative action of procaterol hydrochloride was compatible to or more potent than that of isoproterenol and more potent than that of salbutamol and orciprenaline, as determined by inhibition of increased pulmonary resistance, in dogs, cats and guinea pigs.
(2) Duration of Bronchodilative Action
Procaterenol hydrochloride had a longer duration of action than isoproterenol, trimetoquinol, orciprenaline, or salbutamol in dogs, cats, and guinea pigs.
(3) Selectivity for beta2-adrenergic receptros (Organ Selectivity)
The selectivity of procaterol hydrochloride for beta2-adrenergic receptors in the respiratory system was greater than for such receptors in the cardiovascular system, as compared to isoproterenol, trimetoquinol, orciprenaline, and salbutamol, in dogs, cats and guinea pigs.
(4) Anti-allergic Action
Procaterol hydrochloride exhibited a definite anti-allergic action by inhibiting antibody-induced increases in airway resistance, the PCA reaction and histamine release from sensitized lung tissue in guinea pigs and rats, as well as allergen-induced in bronchial asthma patients, as compared to isoproterenol, trimetoquinol, orciprenaline, and salbutamol. The drug also inhibited allergen-induced delayed-type and immediate-type bronchial response.
(5) Effects on Respiratory Tract System
Procaterol hydrochloride accelerates ciliary activity in the airway of pigeons.
(6) Effect on Exercise-Induced Asthmatic Attacks
Procaterol hydrochloride suppressed treadmill exercise-induced asthmatic attacks in children with bronchial asthma.
(7) Effect on Airway Hypersensitivity
Procaterol hydrochloride inhibits airway hypersensitivity accelerated by the inoculation of influenza virus C in dogs.
(8) Inhibitory Effect on Accelerated Vascular Permeability
Procaterol hydrochloride inhibited the acceleration of vascular permeability and edema formation in dorsal subcutaneous air sacs in rats experimentally prepared using various inflammatory chemical agents. Its potency was similar to that of isoproterenol. Procaterol hydrochloride also inhibited pulmonary edema induced by histamine inhalation in guinea pigs, with greater potency than salbutamol.
(9) Effect on Cough
Procaterol hydrochloride inhibited cough in acute bronchitis induced by inhalation of substance P.
Packaging/ Availability
Procaterol hydrochloride (Meptin Syrup) 5mcg/mL, bottle of 60mL
Storage and Handling
Store at temperature not exceeding 25 degree Celcius. Procaterol hydrochloride (Meptin Syrup) should be protected from light.
Caution: foods, drugs, and cosmetics acts prohibits dispensing without prescription. BFAD registration No. DR-XY 32044
Manufactured by:
Interthai Phamaceutical Manufacturing Ltd.
1899 Phaholyothin Rd., Bangkok Thailand