Drug Study: (MIDAZOLAM)

Brand Name: MIDAZOLAM

CLASSIFICATIONS
Therapeutic:
Anti-anxiety agents, sedative/hypnotics

Pharmacologic:
benzodiazepines

ACTIONS
Physiologic Mechanism

• Short-term sedation

• Postoperative amnesia

Pharmacologic Mechanism

• Acts at many levels of the CNS to produce generalized CNS depression.

• Effects may be mediated by GABA, an inhibitory neurotransmitter.

INDICATION
• Preprocedural sedation.

• Aids in the induction of anesthesia and as part of balanced anesthesia.

NURSING CONSIDERATIONS
• Assess level of sedation and level of consciousness throughout and for 2-6 hr following administration.
• Monitor BP, pulse and respiration continuously during IV administration. Oxygen and resuscitative equipment should be immediately available.
• If overdose occurs, monitor pulse, respiration , and BP continuously. Maintain patent airway and assist ventilation as needed. If hypotension occurs, treatment includes IV fluids, repositioning and vasopressors.
• The effects of midazolam can be reversed with flumazenil (Romazicon).


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