Brand Name: MIDAZOLAM
CLASSIFICATIONS
Therapeutic:
Anti-anxiety agents, sedative/hypnotics
Pharmacologic:
benzodiazepines
ACTIONS
Physiologic Mechanism
• Short-term sedation
• Postoperative amnesia
Pharmacologic Mechanism
• Acts at many levels of the CNS to produce generalized CNS depression.
• Effects may be mediated by GABA, an inhibitory neurotransmitter.
INDICATION
• Preprocedural sedation.
• Aids in the induction of anesthesia and as part of balanced anesthesia.
NURSING CONSIDERATIONS
• Assess level of sedation and level of consciousness throughout and for 2-6 hr following administration.
• Monitor BP, pulse and respiration continuously during IV administration. Oxygen and resuscitative equipment should be immediately available.
• If overdose occurs, monitor pulse, respiration , and BP continuously. Maintain patent airway and assist ventilation as needed. If hypotension occurs, treatment includes IV fluids, repositioning and vasopressors.
• The effects of midazolam can be reversed with flumazenil (Romazicon).
