Drug Study: Senokot

Generic name: standardized senna concentrate
Brand name: Senokot 187 mg Tablet/ granules
Category: laxative

Formulation:
Tablets – each tablet contains 187 mg equivalent standardized senna concentrate
Granules – each teaspoonsful contains 337 mg equivalent standardized senna concentrate

For reliable of functional constipation through gentle, effective peristaltic stimulation.
-have virtually colon-specific action, inducing efficient, yet gentle peristalsis
-does not act by irritation of the colonic mucosa
-have virtually no effect on motility of the stomach and small intestine

Mechanism of action:
Senokot preparations contain glycosides (the natural principles of senna) which, upon ingestion, exert no action in the stomach or small intestine. In the colon, according to current theory, enzymatic action converts the inactive glycosides into active aglycones which act specifically in the large bowel through the auerbach’s plexus to stimulate peristalsis.

Clinically confirmed:
Over a decade of wide clinical experiences and a wealth of published clinical and pharmacologic evidence have established Senokot Tablets/granules as a laxative of choice in functional constipation. Senokot preparations help to:
-relieve and control chronic constipation
-lighten the burden of constipation in the aged
-gently relieve constipation of pregnancy and the puerperium
-counteract and prevent drug-induced constipation
-smoothly relieve post-surgical constipation
-mitigate the hazards of constipation in cardiovascular disorders
-facilitate dieting without constipation
-solve the problem of chronic constipation in chronic illness
-help ease the stress and distress of constipation associated with hemorrhoids

Virtually Free from side effects:
The action of Senoko tablets and granules is virtually limited to the colon. In proper dosage, there is usually no intestinal turmoil, cramping, or gripping that occur with orindary laxatives and harsh purgatives.

Reliable, Gentle yet effective:

Senokot tablets and granules, by their gentle peristaltic stimulation of the colon, help induce comfortable evacuation of well-formed stools, usually within 8 to 10 hours.
This permits administration at bedtime, and easy evacuation the following morning. Its high degree of effectiveness is reflected in satisfactory evacuation achieved in 95.9% of 7,571 patients reported in 31 clinical studies.

High patient acceptance
Delicious chocolate-flavored granules; small, easy to swallow tablets. Optimal dosage flexibility to meet the individual needs of your patients. Economical.

Rehabilitation potential:
Senokot tablets and granules aid in rehabilitation of the constipated patient by facilitating regular elimination.

Dosage and Administration:
Tablets: (preferably at bedtime)
Adult: 2 tablets (maximum dose: 4 tablets two times a day)
Children above 60 lbs (27.27kg): one tablet (Maximum dose: 2 tablets two times a day)

Granules:
Adult: 1 teaspoonful (maximum dose: 2 teaspoonsful twice a day)
Children above 60 lbs (27.27kg): one-half teaspoonful (maximum dose: 1 teaspoonful twice a day)
Dosage can be adjusted to meet individual requirements. If comfortable bowel movement is not achieved by the second day, increase recommended dose by one tablet (up to maximum dosage) or decrease until the most effective dose is established. In granules, decrease or incrase dose by one-half teaspoonful (up to maximum dosage).

Contraindication
do not use when abdominal pain, nausea, vomiting, or other symptoms of appendicitis are present, acute abdominal diseae, intestinal hemorrhage, or obstruction , or persistent diarrhea.

Store at temperature not exceeding 30 degrees Celsius.

Availability:

Senokot 187 mg tablets – Box of 100’s
Senokot Granules – Bottles of 30 g
Senokot Forte 374 mg Tablets – Box of 100’s

Licensed by:

Mundipharma B.V./The Netherlands


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