Generic Name: HYDROCORTISONE Sodium Succinate
Brand Name: (Solu-Cortef)
Dosage: 100 mg, 250 mg, 500 mg Sterile Powder for Injection (IM/IV)
Description
Hydrocortisone sodium succinate or pregn-4-ene-3, 20-dione, 21-(3-carboxy-1-oxopropoxy)-11, 17-dihydroxy;monosodium salt, (11B) is an anti-inflammatory adrenocortical steroid. This highly water-soluble sodium succinate ester of hydrocortisone permits the immediate intravenous administration of high doses of hydrocortisone in a small volume of diluent and is particularly useful where high blood levels of hydrocortisone are required rapidly.
When necessary, the pH of Hydrocortisone sodium succinate was adjusted with Sodium hydroxide so that the pH of the reconstituted solution is within the USP specified range of 7 to 8.
Actions
Hydrocortisone sodium succinate has the same metabolic and anti-inflammatory actions as hydrocortisone. When given parenterally and in equimolar quantities, the two compounds are equivalent in biologic activity. Following the intravenous injection of hydrocortisone sodium succinate, demonstrable effects are evident within one hour and persist for a variable period. Excretion of the administered dose is nearly complete within 12 hours. Thus, if constantly high blood levels are required, injections should be made every 4 to 6 hours. This preparation is also rapidly absorbed when administered intramuscularly and is excreted in a pattern similar to that observed after intravenous injection.
Indications
When oral therapy is not feasible, and the strength, dosage form, and route of administration of the drug reasonably lend the preparation to the treatment of the condition. Hydrocortisone sodium succinate Sterile Powder is indicated for intravenous or intramuscular use in the following conditions:
1.Endocrine Disorders
Primary or Secondary adrenocortical insufficiency. Acute adrenoortical insufficiency. Preoperatively and in the event of serious trauma or illness, in patients with known adrenal insufficiency or when adrenocortical reserve is doubtful. Shock unresponsive to conventional therapy if adrenocortical insufficiency exists or is suspected.
Nonsuppurative thyroiditis
Congenital adrenal hyperplasia
Hypercalcemia associated with cancer
