Directions for Using the Act-O-vial System
1. Press down on plastic activator to force diluent into the lower compartment.
2. Gently agitate to effect solution.
3. Remove plastic tab covering center of stopper.
4. Sterilize top of stopper with a suitable germicide.
5. Insert needle squarely through center of stopper until tip is just visible. Insert vial and withdrawn dose.
Further dilution is not necessary for intravenous or intramuscular injection. For intravenous infusion, first prepare solution as just describe. The 100 mg solution may then be added to 100 to 1000 mL of 5% dextrose in water (or isotonic saline solution or 5% dextrose in isotonic saline solution if patient is not on sodium restriction). The 250 mg solution may be added to 250 to 1000 mL, the 500 mg solution may be adde to 500 to 1000 mL and the 1000 mg solution to 1000 mL of the same diluents. In cases where administration of a small volume of fluid is desirable, 100 mg to 3000 mg of Hydrocortisone sodium sucinate may be added to 50 mL of the above diluents. The resulting solutions are stable for at least 4 hours and may be administered either directly or by IV piggyback.
When reconstituted as directed, pH’s of the solutions range from 7 to 8 and the tonicities are: 100 mg ACT-O-VIAL, 0.36 osmolar; 250 mg ACT-O-VIAL, 500 mg ACT-O-VIAL, and the 1000 mg ACT-O-VIAL, 0.57 osmolar. (Isotonic saline = 0.28 osmolar).
Availability
100 mg vial x 1’s
100 mg ACT-O-VIAL x 1’s
250 mg ACT-O-VIAL x 1’s
500 mg ACT-O-VIAL x 1’s
Storage conditions
Store unreconstituted product at controlled temperature 15 degrees to 30 degrees.
Store solution at controlled temperature 15 degrees to 30 degrees and protect from light. Use solution only if it is clear. Unused solution should be discarded after 3 days.
Cautions
Foods, Drugs, Devices, and Cosmetics Act prohibits dispensing without prescription.