Drug Study: Ketorolac (Toradol)

GENERIC NAME:
Ketorolac

BRAND NAME:
Toradol

CLASSIFICATION:
Nonsteroidal anti-inflammatory agents, nonopioid analagesics

DOSAGE:
30mg/amp1 amp IM

MECHANISM OF ACTION:
- Inhibits prostaglandin synthesis, producing peripherally mediated analgesia
- Also has antipyretic and anti-inflammatory properties.
- Therapeutic effect:Decreased pain

INDICATION:
Short term management of pain (not to exceed 5 days total for all routes combined)

CONTRAINDICATIONS:
- Hypersensitivity
- Cross-sensitivity with other NSAIDs may exist¨Pre- or perioperative use
- Known alcohol intoleranceUse cautiously in:
1) History of GI bleeding
2) Renal impair-ment (dosage reduction may be required)
3) Cardiovascular disease

SIDE EFFECTS/ ADVERSE EFFECTS:
- CNS:
1) drowsiness
2) abnormal thinking
3) dizziness
4) euphoria
5) headache-
- RESP:
1) asthma
2) dyspnea
- CV:
1) edema
2) pallor
3) vasodilation
- GI:
1) GI Bleeding
2) abnormal taste
3) diarrhea
4) dry mouth
5) dyspepsia
6) GI pain
7) nausea
- GU:
1) oliguria
2) renal toxicity
3) urinary frequency
- DERM:
1) pruritis
2) purpura
3) sweating
4) urticaria
- HEMAT:
1) prolonged bleeding time
- LOCAL:
1) injection site pain
- NEURO:
1) paresthesia
- MISC:
1) allergic reaction, anaphylaxis

NURSING IMPLICATIONS/RESPONSIBILITIES:
- Patients who have asthma, aspirin-induced allergy, and nasal polyps are at increased risk for developing hypersensitivity reactions. Assess for rhinitis, asthma, and urticaria.
- Assess pain (note type, location, and intensity) prior to and 1-2 hr following administration.
- Ketorolac therapy should always be given initially by the IM or IV route. Oral therapy should be used only as a continuation of parenteral therapy.
- Caution patient to avoid concurrent use of alcohol, aspirin, NSAIDs, acetaminophen, or other OTC medications without consulting health care professional.
- Advise patient to consult if rash, itching, visual disturbances, tinnitus, weight gain, edema, black stools, persistent headche, or influenza-like syndromes (chills,fever,muscles aches, pain) occur.
- Effectiveness of therapy can be demonstrated by decrease in severity of pain. Patients who do not respond to one NSAIDs may respond to another.


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